DataSet

National Cancer Institute (NCI)

HEAL

The Health, Eating, Activity, and Lifestyle study is designed to: Collect information on anthropometrics, body composition, and hormone measurements from women with early stage breast cancer at a baseline interview and at two years. More limited information on these measures was collected at five years and is currently in the ten-year follow-up phase. Examine the relationship between physical activity, diet, weight history, and body composition and breast cancer prognostic characteristics, including stage, histologic patterns, and clinical tumor grade at diagnosis among women with early stage breast cancer. Examine the relationships between modifiable prognostic factors, including physical activity, diet, body weight and composition, and breast cancer recurrence and survival. Assess the associations of the following with body composition, diet, and physical activity in women with early stage breast cancer: Serum estrone, Estradiol, Testosterone, Sex hormone binding globulin, C-peptide, Insulin-like growth factor (IGF I), Insulin-like growth factor binding protein (IGF 1 BP3), Leptin, Vitamin D, C-reactive protein, and Serum amyloid A. Examine self-reported quality of life and availability of social support at three years post-diagnosis, including information sources and desire for information. More limited information on these measures was collected at five years and is currently in the ten-year follow-up phase. Examine the associations between genetic polymorphisms and the other risk factors collected, in particular, serum sex and metabolic hormones and amount and distribution of fat mass. Examine the associations between mammographic density and other factors and survival.

African Americans; Aged; Breast Neoplasms; European Continental Ancestry Group; Female; Health Status Disparities; Hispanic Americans; Mental Health; Middle Aged; Population Surveillance; Prospective Studies; Quality of Life; Questionnaires; Recovery of Function; Socioeconomic Factors; Survivors; Time Factors; Treatment Outcome

The Health, Eating, Activity, and Lifestyle Study began in 1996. To date, it has enrolled approximately 1,200 women with early stage breast cancer and has completed 2-year and 5-year follow-up. Data collection is currently in the 10-year follow-up phase. Follow-up is both active (at 2 years, 5 years and 10 years for recurrences and updates of exposure variables) and passive (yearly through the respective SEER registries for vital status and second primaries).

Sheps Center, UNC-CH

1967